o3 revisits 376 unsolved pediatric cases and cracks 18 of them
These were families who had been waiting years for an answer about their child's rare disease. The model did not diagnose anything on its own, it proposed leads that doctors then checked and tested. Out of 376 stalled cases, 18 ended up with a confirmed diagnosis.
practitioners › NEJM AI study, June 18 2026, OpenAI's o3 model, 4.8% additional diagnostic yield after expert review.
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